Usually due to higher security settings in Windows VISTA ,Windows 7 machines we often need to run our application / setup exe by right clicking on the file and using [Run as Administrator] option.
But it can done programmatically too. The sample code given below demonstrates it.
[VB.NET CODE STARTS]

Dim procInfo As New ProcessStartInfo()
 
  procInfo.WindowStyle = ProcessWindowStyle.Hidden
  procInfo.UseShellExecute = True
  procInfo.FileName = My.Application.Info.DirectoryPath & "\MYInstaller\setup.exe"
  procInfo.WorkingDirectory = ""
 
  If (My.Computer.Info.OSFullName.ToString.Contains("Vista") = True) Or _
               (My.Computer.Info.OSFullName.ToString.Contains("Windows 7") = True) Then

      procInfo.Verb = "runas"

  End If
 
 Process.Start(procInfo)

[VB.NET CODE ENDS]